Microbial Fermentation Systems

Turnkey Reactor & Control Systems for Microbial Process Development

Designed, developed, and tested to meet the needs & requirements of fermentation professionals

ILS Automation has the technology and engineering expertise to give you precise control over the fermentation of microbial cells from lab to pilot scale applications.

Since 2004, ILS has worked closely with fermentation scientists and engineers to build custom and semi-custom bioreactor controllers and control software that helps them test, optimize, and translate R&D and pilot scale activities into production.

Microbial Fermentation Packages – Single & Dual Controller Systems

Dual Jacketed Reactors with Standard Flow Controller

Dual Unjacketed Reactors with Low Flow Controller (0.05 ml/hr)

Flexible Microbial Fermentation Packages:

  • Choose 2, 3, 5, 7, or 15 Liter Glass Bioreactors
    • Affordably priced and sourced from US-based vendors for quick delivery (Broadley-James, Chemglass)
    • Bioreactor options include microspargers, low-shear impellers, extra blind-nuts, etc.
    • Bioreactors are available as jacketed or unjacketed with a cooling finger
  • Choose from various heating and cooling options
    • Water box: Off-the-shelf components provide superior temperature control
  • Choose the gases and MFC supplier
    • Adjustable gas configurations: Start with air and O2, or just air and add O2 later
  • Choose digital probes, analog probes, or both

  • Built-In Intelligently Integrated Instrumentation

    • Digital probe control (dCO2, dCO2 PID)
    • Analog probe control
    • Digital scales for low fed batch
    • Digital gas flow controllers
    • Digital servo motors
    • Level control for perfusion

  • Accurate Control – Optimize your culture’s growing environment with accurate pH control, temperature control with minimal overshoot, and low-flow fed batch control.

    • 0.1 degree temperature control with blanket or jacket
    • Precise pH control (base and acid) with pumps or CO2. Includes Setpoint and Integral Deadband.
    • Easy-to-use DO Cascade with Air, O2 and RPM, if desired
    • dCO2 control with CO2 and/or Air/N2
    • Accurate and precise low-flow fed batch with variable speed pumps in combination with scales
    • Multi-point calibration curves for low-flow variable speed pumps, accurate control at less than 2 revolutions per hour (approx. 1 gram per hour) to 100 RPM
    • Mass charge with pumps/scales/calibration curve
    • Vessel level control for continuous/perfusion systems utilizing vessel on scale or load cell
    • Setpoint profiles for all control elements and control loops including gas flow controllers and pump flow

  • Software Options – Combine with your existing SCADA or LIMS systems through ILS’s non-proprietary, affordable Batch Expert+ (BE+) software platform, or choose a Kepware Modbus OPC Server. BE+ can integrate a variety of equipment from vendors including Sartorius, Applikon, Eppendorf, Allen-Bradley, etc.

  • Field Upgradeable & Maintainable Microbial Fermentation System – Whether making changes on-site or through your VPN, ILS can continue to update & customize your platform so that it grows along with your changing needs.

    • Menus and operator screens can be customized and updated
    • Open software includes code and documentation
    • Hardware is off-the-shelf industrial grade components, wiring diagrams included
    • This means the user interface to a 10 year-old controller and a new controller will always be the same

  • Outstanding Customer Support – Our customers know us personally and rave about our support, availability, and commitment to their success. We encourage you to ask them.

Yeast photo by Doc. RNDr. Josef Reischig, CSc./CC BY

microbial fermentation bioreactor controller with fermenter afc 927

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